Dale Shepard, MD, PhD: So in terms of reaching out specifically to patients within breast cancer trials and breast cancer care, how big of a role does social media, patient support groups, how big of a role does that play in terms of patient awareness of a trial … Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. All trials on the list are supported by NCI. This service is more advanced with JavaScript available, Landmark Trials in Oncology Krag D, et al. Trials measured cancer severity in terms of clinical stage (0 to IV), 23, 24, 68, 69 number of involved lymph nodes (0, 1 to 3, or ≥4), 18, 20, 25, 26, 70 and tumor size (mm), 19, 21, 26 and these varied across trials. We have provided a summary of key annoucements. N Engl J Med. The clinical trial will take place in three Canadian centers, including the Cross Cancer Institute in Edmonton, and will enroll patients with advanced and previously treated lymphoma, breast, … 11 Year follow up of trastuzumab after adjuvant chemotherapy in HER2-positive early breast cancer: final analysis of the HERceptin adjuvant (HERA) trial. Desmoid tumors 28. Basal cell carcinoma (temporarily closed to accrual 04 / 29 / 2020) 42. Blocking PARP may help keep cancer cells from repairing their damaged DNA, causing them to die. For more information on participating in a trial … This study will help to determine if regional radiotherapy can be omitted for low risk ER positive node positive breast cancer patients. The 2020 conference went online and saw a number of clinically significant results presented that will help inform the treatment of breast cancer in the clinic and guide further clinical trials. Clinical trials look at new ways to prevent, detect, or treat disease. Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Patients in this study will be randomly assigned to get either tucatinib or placebo (a pill with no medicine). Extrahepatic cholangiocarcinoma and bile duct tumors (closed to accrual 03 / 20 / 2018) 11. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Patients will swallow tucatinib pills or placebo pills two times every day. Earlier data from the trial, led to the FDA approval of the antibody-drug conjugate in December 2019 in adult patients with unresectable or metastatic HER2-positive breast cancer who … Location: 1034 locations, This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Small cell lung cancer is not eligible (temporarily closed to accrual 03 / 25 / 2020) 52. This may also predict for increased benefit with immunotherapy. Epithelial tumors of major salivary glands (closed to accrual 03 / 20 / 2018) 3. … Location: 1201 locations, This randomized phase III trial studies how well doxorubicin hydrochloride and cyclophosphamide followed by paclitaxel with or without carboplatin work in treating patients with triple-negative breast cancer. Trophoblastic tumor: A) Choriocarcinoma (closed to accrual) 15. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body’s immune system attack the tumor, and may interfere with the ability of tumor cells to grow and spread. Clinical trials are research studies that involve people. Fisher B, et al. 2014;15:1303–10. BRCA-P is an international breast cancer prevention clinical trial which will enrol 2918 patients. At the moment they recommend that women at high or moderate risk of breast cance… It is open to women with a confirmed BRCA1 gene mutation who have not had a diagnosis of breast cancer. Over 10 million scientific documents at your fingertips. Trastuzumab is a form of “targeted therapy” because it works by attaching itself to specific molecules (receptors) on the surface of cancer cells, known as HER2 receptors. Trials have looked at hormone therapies including: 1. tamoxifen 2. raloxifene 3. anastrozole (Arimidex) The results show that these drugs can lower the risk of breast cancer in women at high risk. The IES trial was designed as an international, multicenter, randomized, double‐blind trial to compare the efficacy and safety of continued adjuvant tamoxifen therapy with exemestane therapy in postmenopausal women with primary breast cancer … Lancet Oncol. Drugs used in chemotherapy, such as vinorelbine tartrate, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. ... Summary. Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741. Location: 575 locations, This randomized phase III trial studies how well paclitaxel, trastuzumab, and pertuzumab with or without atezolizumab works in treating patients with breast cancer that has spread to other parts of the body (metastatic). Randomized data on chemoprevention • Prospective, double-blind, randomized trial • Involved 19,747 postmenopausal females and studied tamoxifen versus raloxifene in preventing breast cancer • The final analysis initiated after at least 327 incident invasive breast cancers were diagnosed: 163 and 168 cases of invasive breast cancer in tamoxifen and raloxifene treated groups • No differences were found for other invasive cancer … A 15-year meta-analysis conducted by the Early Breast Cancer Trialists’ Collaborative Group of long-term outcomes among 100,000 women treated in 123 randomized trials to evaluate polychemotherapy demonstrated a 10-year breast cancer … Carcinomas of pituitary gland, thyroid gland parathyroid gland and adrenal cortex (closed to accrual) 27. Each treatment cycle lasts 21 days. Bonadonna G, et al. N Engl J Med. Lancet. Olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Small cell carcinoma of the ovary, hypercalcemic type 49. JAMA. Ask whether the combination of drugs proposed for your chemotherapy have been through clinical trials 2017;377:122–31. It is not known whether patients with low risk breast cancer need to receive regional radiotherapy. The Early Breast Cancer Trialists’ Collaborative Group meta-analysis evaluated which patients benefited from postmastectomy radiation therapy. Sparano JA, et al. Intrahepatic cholangiocarcinoma (closed to accrual 03 / 20 / 2018) 10. Over the past 40 years, breast cancer treatment has greatly improved due to lessons learned through clinical trials. Not Otherwise Categorized (NOC) Rare Tumors [To obtain permission to enroll in the NOC cohort, contact: S1609SC@swog.org] (closed to accrual 03 / 15 / 2019) 34. Cleveland Clinic researchers are getting ready to embark on a clinical trial testing a breast cancer vaccine. The Breast Cancer Locator study is a prospective, 1:1 randomized, controlled pivotal trial that will enroll 448 women with non-palpable invasive breast cancer or ductal carcinoma in situ (DCIS) … The CALGB 9343 trial evaluated the role of post-lumpectomy radiation in an older population of ER-positive patients and is discussed. Chemotherapy drugs, such as cisplatin, carboplatin, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981-22023 AMAROS): a randomized, multicenter, open label, phase 3 non-inferiority trial. When trastuzumab attaches to HER2 receptors, the signals that tell the cells to grow are blocked and the tumor cell may be marked for destruction by the body’s immune system. Fisher B, et al. Immunotherapy with monoclonal antibodies, such as atezolizumab, may induce changes in body’s immune system and may interfere with the ability of tumor cells to grow and spread. Donker M, et al. Drugs used in chemotherapy, such as doxorubicin hydrochloride, cyclophosphamide, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The National Institute for Health and Clinical Excellence (NICE) provide guidance for women at higher risk of breast cancer. Effect of Radiotherapy After Mastectomy and Axillary Surgery on 10-year Recurrence and 20-year Breast Cancer Mortality: Meta-analysis of Individual Patient Data from 8135 Women in 22 Randomized Trials. Sarcomatoid carcinoma of lung 12. It is not yet known whether doxorubicin hydrochloride and cyclophosphamide is more effective when followed by paclitaxel alone or paclitaxel and carboplatin in treating triple-negative breast cancer. Adenocarcinoma with variants of GU system (excluding prostate cancer) (closed to accrual 07 / 27 / 2018) 21. The study consists of two stages: in the Dose Escalation Stage, an appropriate recommended cabozantinib dose for the combination with standard dosing regimen of atezolizumab will be established; in the Expansion Stage, tumor-specific cohorts will be enrolled in order to further evaluate the safety and efficacy of the combination treatment in these tumor indications. Squamous cell carcinoma with variants of GI tract (stomach small intestine, colon, rectum, pancreas) (closed to accrual 10 / 17 / 2018) 7. The ACOSOG Z0011, AMAROS, and MA-20 trials evaluated regional nodal management and are included. When trastuzumab attaches to HER2 receptors, the signals that tell the cells to grow are blocked and the cancer cell may be marked for destruction by the body's immune system. J Clin Oncol. 2017;318(10):918–26. Location: 15 locations, This randomized, phase II trial studies how well fulvestrant or exemestane with or without ribociclib works in treating patients with hormone receptor positive, human epidermal growth factor receptor 2 (HER2) negative breast cancer that has progressed after treatment with an aromatase inhibitor or cyclin-dependent kinase 4 / 6 inhibitor (recurrent), cannot be removed by surgery (unresectable), or has spread to other parts of the body (metastatic). Treatment of lymph node negative, oestrogen-receptor positive breast cancer: long term findings from National Surgical Adjuvant Breast and Bowel Project randomized clinical trials. This randomized phase III trial studies whether weight loss in overweight and obese women may prevent breast cancer from coming back (recurrence). The clinical trials on this list are for breast cancer. Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study. Intensive dose-dense compared with high-dose adjuvant chemotherapy for high-risk operable breast cancer: Southwest Oncology Group/Intergroup Study 9623. 2010;28:5132–9. evaluated the optimal sequencing of chemotherapy and are discussed. The vaccine was developed by researchers at the Cleveland Clinic in Ohio and works by training the … the results of 20 years of follow-up. Background: Breast cancer patients have a lifelong 2-4-fold increased risk of developing a second primary tumor in the contralateral breast compared with the risk for a first primary breast cancer in the general female population. The study has randomized more than 10,200 women with this type of breast cancer at 1,182 sites in the … Location: 23 locations, This is an open-label, multicenter, global Phase 2 basket study of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor an NTRK1 / 2 / 3, ROS1, or ALK gene fusion. Three studies are included that lessened the burden of surgery including the NSABP B-04, NSABP B-06, and NSABP B-32 trials. Investigators will test new tableted preparation, V3-MOMMO, obtained from hydrolyzed, inactivated blood and tumor tissues of patients with breast cancer. One exploratory single-agent atezolizumab (SAA) cohort may also be enrolled with CRPC subjects. Rare pancreatic tumors including acinar cell carcinoma, mucinous cystadenocarcinoma or serous cystadenocarcinoma. 1995;332(14):901–6. N Engl J Med. US - Breast Cancer Clinical Trials Overview 5.1 By Drug Class 5.2 By Formulation 5.3 By Organization 5.4 By Patient Segment 5.5 By Phase 5.6 By Target 6. It is not known whether giving olaparib with or without atezolizumab will work better in patients with non-HER2-positive breast cancer. Study Summary: The main purpose of this study is to learn if the usual chemotherapy given before surgery (neoadjuvant therapy) for breast cancer plus the experimental drug, atezolizumab, is better … 2010;11(10):927–33. Cancer and Leukemia Group B (CALGB) 9343: Lumpectomy plus tamoxifen with or without irradiation in women age 70 years or older with early breast cancer: long-term follow-up of CALGB 9343. It is not yet known whether giving paclitaxel, trastuzumab, and pertuzumab with or without atezolizumab may kill more tumor cells. Endometrial carcinosarcoma (malignant mixed Mullerian tumors) (closed to accrual) 45. PD-L1 amplified tumors 50. PARP inhibitors are a type of targeted therapy. Perez E, et al. J Natl Cancer Inst. Women with ER positive breast cancer normally will receive endocrine therapy and some may receive chemotherapy to help prevent the cancer from coming back. 2017;389:1195–205. Ask whether the combination of drugs proposed for your chemotherapy have been through clinical trials This study aims to test whether overweight or obese women who take part in a weight loss program after being diagnosed with breast cancer have a lower rate of cancer recurrence as compared to women who do not take part in the program. The Breast Cancer Prevention Trial (BCPT) was designed to see whether taking the drug tamoxifen (Nolvadex®) could prevent breast cancer in women who are at an increased risk of developing the … Giving fulvestrant with or without palbociclib and avelumab may work better in treating patients with breast cancer. The Southwest Oncology Group/Intergroup Study 9623 demonstrated that there was no survival advantage to using stem cell transplant over more standard chemotherapy and is included. Location: 62 locations, This randomized phase II trial studies how well olaparib with or without atezolizumab work in treating patients with non-HER2-positive breast cancer that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection (locally advanced unresectable) or has spread to other places in the body (metastatic). SUNNYVALE, Calif., Jan. 19, 2021 /PRNewswire/ -- Accuray Incorporated (NASDAQ: ARAY) announced today that data from a prospective, phase II trial of 338 women with low-risk breast cancer … NSABP-B04: Twenty-five year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation. Radiation therapy is an important treatment for breast cancer, however, radiation goes to other organs, such as heart, causing heart problems. 2013;31(19):2382–7. Location: 848 locations, This trial studies how well paclitaxel, trastuzumab, and pertuzumab work in eliminating further chemotherapy after surgery in patients with HER2-positive stage II-IIIa breast cancer who have no cancer remaining at surgery (either in the breast or underarm lymph nodes) after pre-operative chemotherapy and HER2-targeted therapy. Fisher B, et al. Patients with genetic abnormalities (such as mutations, amplifications, or translocations) may benefit more from treatment which targets their tumor's particular genetic abnormality. 1999;353:1993–2000. NSABP trials were among the first to demonstrate that the oral hormonal therapy, tamoxifen, could reduce the risk of breast cancer recurrence and improve survival. Use of molecular tools to identify patients with indolent breast cancers with ultralow risk over 2 decades. 2015;372:724–34. J Clin Oncol. Lancet. Lancet. FAST-Forward Lay Summary of Main Trial Results, v1.0 07/05/2020 1 Clinical trial testing a 1-week course of curative breast radiotherapy against a standard 3-week schedule in early breast cancer The FAST-Forward Trial … 2018;379:111–21. 2007;25:1677–82. Abstract. Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomized trials. Trastuzumab is a form of targeted therapy because it attaches itself to specific molecules (receptors) on the surface of cancer cells, known as HER2 receptors. Three studies are included that lessened the burden of surgery including the NSABP B-04, NSABP B-06, and NSABP B-32 trials. The Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741 and a meta-analysis by Mauri et al. Location: 544 locations, This randomized phase III trial studies if not giving regional radiotherapy is just as good as using regional radiotherapy in keeping breast cancer from coming back in patients with estrogen receptor (ER) positive, HER2 negative node positive low risk breast cancer who have undergone breast conserving surgery or mastectomy. Gestational trophoblastic disease (GTD) 47. Proton therapy is a type of radiation therapy that uses multiple beams of protons (tiny particles with a positive charge) to kill tumor cells. The PRADA (Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy) trial was a 2 x 2 factorial, randomized controlled trial of candesartan and metoprolol in women with early breast cancer … N Engl J Med. We searched PubMed and oncology congress websites (American Society of Clinical Oncology, San Antonio Breast Cancer Symposium, European Society of Medical Oncology) between Jan 1, 2000, and Sept 1, 2015, to identify clinical trials of CDK4/6 inhibitors in combination with adjuvant endocrine therapy for patients with oestrogen-receptor-positive, HER2-negative early breast cancer… Epithelial tumors of penis - squamous adenocarcinoma cell carcinoma with variants of penis 18. At present, upon completion of chemotherapy and surgery, the standard of care for patients with triple-negative breast cancer is observation. 2005;97(22):1652–62. Stopeck A, et al. N Engl J Med. 2017;3(11):1503–10. Adjuvant chemotherapy guided by a 21-gene expression assay in breast cancer. A recent trial (Lancet 2006) confirms that Herceptin offers benefit with early stage breast cancer patients too. Participants with ER+/HER2- breast cancer … Trastuzumab is a form of “targeted therapy” because it works by attaching itself to specific molecules (receptors) on the surface of tumor cells, known as HER2 receptors. In response to COVID-19, some breast cancer trials have temporarily stopped enrolling new patients. Location: 21 locations, The purpose of this study is to further advance the ability to practice personalized medicine by learning which new drug agents are most effective with which types of breast cancer tumors and by learning more about which early indicators of response (tumor analysis prior to surgery via magnetic resonance imaging (MRI) images along with tissue and blood samples) are predictors of treatment success. Ten new clinical trials for TNBC, HER2 positive, and other subtypes of metastatic (stage IV) breast cancer have been added to BreastCancerTrials.org (BCT) in the last month. Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09 / 19 / 2018) 29. Previous studies have found that women who are overweight or obese when their breast cancer is found (diagnosed) have a greater risk of their breast cancer … However, recent studies have shown that giving capecitabine after completion of chemotherapy and surgery is a better treatment than receiving no treatment and also that platinum-based chemotherapy after surgery could prevent residual triple-negative breast cancer from returning. Peritoneal mesothelioma (temporarily closed to accrual 05 / 08 / 2020) 41. Announcing data from a prospective, phase II trial, Accuray (NASDAQ:ARAY) says that women with low-risk breast cancer who were treated with its TomoTherapy (“TOMO”)® System … Be sure to use the contact information in our trial listings to call or email the research site for information about a trial's status. Giving paclitaxel, trastuzumab, and pertuzumab may enable fewer chemotherapy drugs to be given without compromising patient outcomes compared to the usual treatment. Patients will get T-DM1 injections from the study site staff on the first day of every cycle. J Natl Cancer Inst. Moore HCF, et al. However, it is not yet known whether proton therapy is more effective than photon therapy in treating patients with non-metastatic breast cancer without causing heart damage. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. 2003;21:1431–9. These trials relate to the multidisciplinary management of breast cancer from the perspective of a radiation oncologist. Cite as. This is a preview of subscription content. You may want to think about taking part in a clinical trial. Bronchoalveolar carcinoma lung. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Whelan T, et al. The dietary modification trial studied the effect of a diet low in fat and high in fruits, vegetables, and grains on the prevention of breast and colorectal cancer and heart disease. Location: 1083 locations, This randomized phase III trial studies lymph node dissection and radiation therapy to see how well it works compared to radiation therapy alone in treating patients with breast cancer previously treated with chemotherapy and surgery. that evaluated a MammaPrint risk stratification system are included as representative of how molecular and genetic innovations promise to transform cancer management. Location: 1372 locations, This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Gastrointestinal stromal tumor (GIST) (closed to accrual 09 / 26 / 2018) 38. It is not yet known if radiation therapy works better alone or with lymph node dissection in treating patients with breast cancer previously treated with chemotherapy and surgery. Trials have looked at hormone therapies including: 1. tamoxifen 2. raloxifene 3. anastrozole (Arimidex) The results show that these drugs can lower the risk of breast cancer in women at high risk. The vaccine was developed by researchers at the Cleveland Clinic in Ohio and works by training the … Olaparib is an inhibitor of PARP, an enzyme that helps repair deoxyribonucleic acid (DNA) when it becomes damaged. Location: 26 locations, This is a multicenter Phase 1b, open-label study to assess safety, tolerability, preliminary efficacy, and pharmacokinetics (PK) of cabozantinib taken in combination with atezolizumab in subjects with multiple tumor types, including advanced urothelial carcinoma (UC) (including bladder, renal pelvis, ureter, urethra), renal cell carcinoma (RCC), castration-resistant prostate cancer (CRPC), non-small-cell lung cancer (NSCLC), triple negative breast cancer (TNBC), ovarian cancer (OC), endometrial cancer (EC), hepatocellular cancer (HCC), gastric cancer / gastroesophageal junction cancer / lower esophageal cancer (GC / GEJC / LEC), colorectal cancer (CRC), head and neck (H&N) cancer, and differentiated thyroid cancer (DTC). Genetic innovations promise to transform cancer management beams to kill tumor cells and shrink.... 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