Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma. There are two parts to this study. Location: 3 locations, This study is designed to primarily evaluate the safety and efficacy of U3-1402 in participants with advanced or metastatic colorectal cancer (CRC) who have received at least 2 prior lines of therapy and will explore clinical benefit according to human epidermal growth factor receptor 3 (HER3) tumor expression level in otherwise refractory tumors. In Part A, the treatment will be given to participants every 3 weeks (3-week cycles). Trophoblastic tumor: A) Choriocarcinoma (closed to accrual) 15. Squamous cell carcinoma variants of the genitourinary (GU) system 19. About 606,880 Americans are expected to die of cancer in 2019 (Table 1), which translates to about 1,660 deaths per day. Patients with genetic abnormalities (such as mutations, amplifications, or translocations) may benefit more from treatment which targets their tumor's particular genetic abnormality. Finding ctDNA in the blood means that there are very likely small amounts of cancer remaining after surgery that may not be detectable using other tests, such as medical imaging. You may want to think about taking part in a clinical trial. Location: 22 locations, This phase II / III trial studies how well circulating tumor deoxyribonucleic acid (ctDNA) testing in the blood works to identify patients with stage IIA colon cancer who might benefit from additional treatment with chemotherapy after surgery. This study is being done to determine whether there are differences in cancer recurrence in ctDNA positive patients treated with additional therapy versus put on active surveillance. This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Location: 1201 locations, This phase III trial studies how well vitamin D3 given with standard chemotherapy and bevacizumab works in treating patients with colorectal cancer that has spread to other parts of the body (advanced or metastatic). Location: 28 locations, This is an open-label, multicenter, multinational, Phase 2 basket study exploring the efficacy and safety of neratinib as monotherapy or in combination with other therapies in participants with HER (EGFR, HER2) mutation-positive solid tumors. Savolitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Peritoneal mesothelioma (temporarily closed to accrual 05 / 08 / 2020) 41. All trials on the list are supported by NCI. Giving TAS-102, irinotecan, and bevacizumab may work better in treating patients with colorectal cancer compared to traditional chemotherapy and bevacizumab. Cell tumor of the testes and extragonadal germ tumors: A) Seminoma and testicular sex cord cancer B) Non-seminomatous tumor C) Teratoma with malignant transformation (closed to accrual) 17. Written by Monica Beyer on May 5, 2019 — Fact checked by Carolyn Robertson. Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09 / 19 / 2018) 29. Location: 12 locations, Study of NGM120 in subjects with advanced solid tumors and pancreatic cancer. Fibromixoma and low grade mucinous adenocarcinoma (pseudomixoma peritonei) of the appendix and ovary (closed to accrual 03 / 20 / 2018) 8. Part 2B of the study will examine the safety and clinical activity of dostarlimab in cohorts of participants with specific types of advanced solid tumors. NAC for colon cancer improves surgical outcomes and can now be considered as a treatment option; longer follow-up and further trials are required to confirm the long-term benefits, refine its use and optimise case selection. Besides an ageing population and dietary habits of high-income countries, unfavourable risk factors such as obesity, lack of physical exercise, and smoking increase the risk of colorectal cancer. Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma. Jan 5, 2021. It is not yet known whether giving high-dose vitamin D3 in addition to chemotherapy and bevacizumab would extend patients time without disease compared to the usual approach (chemotherapy and bevacizumab). MetaPLASTIC carcinoma (of the breast) (closed to accrual) 37. Endometrial carcinosarcoma (malignant mixed Mullerian tumors) (closed to accrual) 45. When trastuzumab attaches to HER2 receptors, the signals that tell the cells to grow are blocked and the cancer cell may be marked for destruction by the body’s immune system. Treatment for advanced colon cancer took its toll on Corina Ramirez, a young mother of 2. This is genetic material unique to the cancer that may be present in the blood stream and can be identified through a ctDNA blood test. Location: 741 locations, This phase III trial studies combination chemotherapy and atezolizumab to see how well it works compared with combination chemotherapy alone in treating patients with stage III colon cancer and deficient deoxyribonucleic acid (DNA) mismatch repair. Location: 741 locations, This phase III trial studies combination chemotherapy and atezolizumab to see how well it works compared with combination chemotherapy alone in treating patients with stage III colon cancer and deficient deoxyribonucleic acid (DNA) mismatch repair. Cabozantinib-s-malate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Growth factor antagonists, such as regorafenib, may interfere with the growth factor and stop the tumor from growing. The Colon Cancer Foundation and the American Cancer Society have joined forces on an initiative called 80% in Every Community, which challenges you to take a stand against one of the most preventable forms of cancer – colorectal cancer – by getting screened, choosing a healthy way of eating and being physically active. Clinical trials look at new ways to prevent, detect, or treat disease. After completing the questions, you … All trials on the list are supported by NCI. Chemotherapy drugs, such as leucovorin calcium, fluorouracil, oxaliplatin, and irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The study will be conducted in 2 parts: with Part 1 consisting of dose escalation and Part 2 dose expansion. Bronchoalveolar carcinoma lung. Bevacizumab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Sarcomatoid carcinoma of lung 12. Location: 28 locations, This trial studies how well the drug tucatinib works when given with trastuzumab and when given by itself. When this mutation is present, it switches on pathway called the MAPK pathway which stimulates cell division and leads to uncontrolled cell growth. In the first part of this study, participants enrolled into Cohort A and received both tucatinib and trastuzumab. Giving trastuzumab and pertuzumab may work better compared to cetuximab and irinotecan hydrochloride in treating patients with colorectal cancer. Testing for ctDNA levels may help identify patients with colon cancer who benefit from receiving chemotherapy after surgery. [button] Download the Clinical Trials Mini Magazine [/button] Adenocarcinoma with variants of small intestine (closed to accrual 05 / 10 / 2018) 6. Drugs used in chemotherapy, such as irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Physically and emotionally drained from chemotherapy, she was unable to care for her family the way … Location: 11 locations, This is a Phase 1, multiple dose, ascending dose escalation study to define a MTD / RD and regimen of XmAb23104, to describe safety and tolerability, to assess PK and immunogenicity, and to preliminarily assess anti-tumor activity of XmAb23104 monotherapy and combination therapy with ipilimumab in subjects with selected advanced solid tumors. Cancer researchers believe that ctDNA in the blood stream may be an indicator that cancer is more likely to recur. Researchers at Memorial Sloan Kettering are exploring new therapies and diagnostic tools for colon and rectal cancer. Giving vitamin D3 with chemotherapy and bevacizumab may work better in shrinking or stabilizing colorectal cancer. Location: Mayo Clinic in Rochester, Rochester, Minnesota, Treatment Clinical Trials for Colon Cancer, Complementary & Alternative Medicine (CAM), Coping with Your Feelings During Advanced Cancer, Late Effects of Childhood Cancer Treatment, Frederick National Laboratory for Cancer Research, Milestones in Cancer Research and Discovery, Tech Transfer & Small Business Partnerships, Step 1: Application Development & Submission, How to Work With Your Health Insurance Plan, Questions to Ask about Treatment Clinical Trials, Drugs Approved for Different Types of Cancer, Drugs Approved for Conditions Related to Cancer, Targeted Therapy Directed by Genetic Testing in Treating Patients with Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial), Vitamin D3 with Chemotherapy and Bevacizumab in Treating Patients with Advanced or Metastatic Colorectal Cancer, SOLARIS Trial, Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients with Locally Advanced or Metastatic HER2 / Neu Amplified Colorectal Cancer That Cannot Be Removed by Surgery, Combination Chemotherapy with or without Atezolizumab in Treating Patients with Stage III Colon Cancer and Deficient DNA Mismatch Repair, Savolitinib in Treating Patients with MET Amplified Metastatic or Unresectable Colorectal Cancer, Tucatinib Plus Trastuzumab in Patients With HER2+ Colorectal Cancer, Circulating Tumor DNA Testing in Predicting Treatment for Patients with Stage IIA Colon Cancer After Surgery, COBRA Trial, Phase 1 / 2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Patients With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors, A Phase Ib Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Cibisatamab in Combination With Atezolizumab After Pretreatment With Obinutuzumab in Participants With Previously Treated Metastatic Colorectal Adenocarcinoma, Cabozantinib-S-Malate and Panitumumab in Treating Patients with Colorectal Cancer That is Metastatic or Cannot Be Removed by Surgery, Panitumumab, Regorafenib, or TAS-102, in Treating Patients with Metastatic and / or Unresectable RAS Wild-Type Colorectal Cancer, A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Metastatic Colorectal Cancer (Morpheus-CRC), A Phase 1 / 2 Safety Study of Intratumorally Dosed INT230-6, A Study of RO7198457 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Tumors, Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158 / KEYNOTE-158), Early Identification and Treatment of Occult Metastatic Disease in Stage III Colorectal Cancer, FOLFOXIRI Plus Panitumumab in Metastatic RAS Wild-type, Left-sided Colorectal Cancer, TAS-102, Irinotecan, and Bevacizumab for the Treatment of Pre-treated Metastatic or Unresectable Colorectal Cancer, the TABAsCO Study, A Phase 2 Study of NIR178 in Combination With PDR001 in Patients With Solid Tumors and Non-Hodgkin Lymphoma, A Study to Evaluate U3-1402 in Subjects With Advanced or Metastatic Colorectal Cancer, A Study of PSB205 in Subjects With Advanced Solid Tumors, TAS-102 and Oxaliplatin for the Treatment of Refractory Stage IV Colon Cancer, CBP501, Cisplatin and Nivolumab in Advanced Refractory Tumors, Transcriptional Targets of Vitamin D in Patients with Stage I-III Colon Cancer or Resectable Colon Cancer Liver Metastases Receiving Preoperative Cholecalciferol, Heated Intra-peritoneal Chemotherapy with Doxorubicin and Cisplatin for the Treatment of Resectable, Refractory, or Recurrent Abdominal or Pelvic Tumors in Pediatric Patients, T.O.A.S.T. J Clin Oncol. January 23, 2019—The burden of colorectal cancer is staggering. This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Clinical trials look at new ways to prevent, detect, or treat disease. Vitamin D3 may also modulate the immune system and is being studied in the prevention and treatment of some types of cancer. Adenoid cystic carcinoma (closed to accrual 02 / 06 / 2018) 35. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Chemotherapy drugs, such as leucovorin, fluorouracil, and irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Clinical trial … Clinical trials are research studies that involve people. Heated intra-peritoneal chemotherapy is a procedure performed in combination with abdominal surgery for cancer that has spread to the abdomen. Trastuzumab is a form of “targeted therapy” because it works by attaching itself to specific molecules (receptors) on the surface of cancer cells, known as HER2 receptors. The study will be conducted in 2 parts. Location: 5 locations, This is a phase II, open-label, non-randomized study in subjects with histologically confirmed diagnosis of left-sided RAS WT advanced adenocarcinoma of the colon or rectum who have not received prior systemic therapy for metastatic disease. It works by attaching to and blocking a molecule called PD-1. When vitamin D binds to the receptor in the cancer cells, it may stop cancer cells from growing abnormally and may cause cell death. Location: 16 locations, CO40939 is a Phase Ib, open-label, multicenter, single-arm study designed to evaluate the safety, efficacy, pharmacokinetics, and immunogenicity of cibisatamab in combination with atezolizumab administered after pretreatment with obinutuzumab in patients with Stage IV microsatellite stable (MSS) metastatic colorectal cancer (mCRC) whose tumors have high carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) expression and who have progressed on two or more chemotherapy regimens. This condition is now also referred to as adenocarcinoma in situ, minimally invasive adenocarcinoma, lepidic predominant adenocarcinoma, or invasive mucinous adenocarcinoma 13. Table 3 provides estimated cancer deaths by state in 2019. Clinical trials are a type of medical research used to test cutting edge approaches for treating or diagnosing disease, including cancer. Epithelial tumors of nasal cavity, sinuses, nasopharynx: A) Squamous cell carcinoma with variants of nasal cavity, sinuses, and nasopharynx and trachea (excluding laryngeal, nasopharyngeal cancer [NPC], and squamous cell carcinoma of the head and neck [SCCHN]) B) Adenocarcinoma and variants of nasal cavity, sinuses, and nasopharynx (closed to accrual 07 / 27 / 2018) 2. BRAF inhibitor encorafenib 2. Three exploratory single-agent cabozantinib (SAC) cohorts may also be enrolled with UC, NSCLC, or CRPC subjects. Location: 16 locations, This study will evaluate the safety profile, tolerability, PK, PD, and preliminary efficacy of BMS-813160 alone or in combination with either chemotherapy or nivolumab in participants with metastatic colorectal and pancreatic cancers. Nowadays, it is the world's fourth most deadly cancer with almost 900 000 deaths annually. Clinical trials … Colorectal cancer is a cancer that starts in the colon or the rectum. The study will be conducted in 2 parts with Part 1 consisting of safety evaluation, pharmacokinetics (PK), and pharmacodynamics (PDy) of escalating doses of dostarlimab. Intrahepatic cholangiocarcinoma (closed to accrual 03 / 20 / 2018) 10. Not Otherwise Categorized (NOC) Rare Tumors [To obtain permission to enroll in the NOC cohort, contact: S1609SC@swog.org] (closed to accrual 03 / 15 / 2019) 34. Extrahepatic cholangiocarcinoma and bile duct tumors (closed to accrual 03 / 20 / 2018) 11. 2009;27:3109-3116. Cetuximab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Nov. 25, 2019 — Two genes that appear to help stem cells in the intestine burn dietary fat may play a role in colon cancer, according to a new study. Colorectal cancer is the second leading cause of cancer death in the United States. If all the cancer is not killed after initial treatment, bloods tests may be able to detect tumor DNA in the blood called circulating tumor DNA (ctDNA). Location: 6 locations, This is a Phase 1a / 1b, open-label, multicenter, global, dose-escalation study designed to evaluate the safety, tolerability, immune response, and pharmacokinetics of RO7198457 as a single agent and in combination with atezolizumab (MPDL3280A, an engineered anti-programmed death-ligand 1 [anti-PD-L1] antibody). Location: 18 locations, A phase Ib / II, open-label, multicenter, randomized study designed to assess the safety, tolerability, pharmacokinetics and preliminary anti-tumor activity of immunotherapy-based treatment combinations in patients with metastatic colorectal cancer (mCRC) that became refractory to first- and second-line standard therapies. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. ) 32 07 / 27 / 2018 ) 29 clinical trials on list. 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